Headache in association with sleep disorders in children: a psychodiagnostic evaluation and controlled clinical study--L-5-HTP versus placebo

Drugs Exp Clin Res. 1987;13(7):425-33.


Forty-eight elementary and junior high school students presenting the association of recurring headache and sleep disorders were selected for this study on the basis of a questionnaire filled out by the entire school population. The selected students had normal intellectual capacity but often showed inadequate progress in school, attentive-mnemonic deficiencies, and psychopathological elements of a depressive nature. The clinical characteristics predicted that this group would be responsive to treatment with L-5-hydroxytryptophan. The results of a double-blind, cross-over trial with placebo confirmed these expectations for headache and some sleep disorders, in particular frequent awakenings and some parasomnias.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • 5-Hydroxytryptophan / adverse effects
  • 5-Hydroxytryptophan / therapeutic use*
  • Adolescent
  • Child
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Headache / drug therapy*
  • Headache / etiology
  • Headache / psychology
  • Humans
  • Male
  • Random Allocation
  • Sleep Wake Disorders / complications*
  • Time Factors


  • 5-Hydroxytryptophan