Ménétrier Disease

Excerpt

Ménétrier disease is a rare disorder characterized by giant mucosal folds in the proximal stomach, reduced acid secretion, and protein-losing enteropathy with resulting hypoalbuminemia. The distal stomach is typically spared. Alternative terms include "hypoproteinemic hypertrophic gastropathy" and "giant hypertrophic gastritis." The condition predominantly affects men but also occurs in women and children. In adults, Ménétrier disease frequently follows a progressive course and is considered premalignant. The etiopathogenesis is incompletely understood.