Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr;174(4):572-576.
doi: 10.7326/M20-4986. Epub 2020 Oct 21.

COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study of 8 Million Adults

Ashley Kieran Clift  1 , Carol A C Coupland  2 , Ruth H Keogh  3 , Harry Hemingway  4 , Julia Hippisley-Cox  1
Affiliations

COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study of 8 Million Adults

Ashley Kieran Clift et al. Ann Intern Med. 2021 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-4986.

Figures

Figure.
Figure.. Adjusted HR (95% CI) for the association between Down syndrome and death from COVID-19.
Adjusted for the variables shown, deprivation, fractional polynomial terms for body mass index (BMI), and age. The model includes fractional polynomial terms for age, BMI, and interaction terms between age terms and type 2 diabetes. We used the QResearch database, version 44. The study period was 24 January 2020 to 30 June 2020. CF = cystic fibrosis; COVID-19 = coronavirus disease 2019; GP = general practitioner; HR = hazard ratio; LABA = long-acting β2-agonist; MND = motor neurone disease; MS = multiple sclerosis; SLE = systemic lupus erythematosus. * HR for type 2 diabetes reported at mean age.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Espinosa JM. Down syndrome and COVID-19: a perfect storm? Cell Rep Med. 2020;1:100019. [PMID: 32501455] doi:10.1016/j.xcrm.2020.100019 - PMC - PubMed
    1. Development of a COVID-19 risk prediction model. Nuffield Department of Primary Care Health Sciences. 2020. Accessed at www.phc.ox.ac.uk/research/primary-care-epidemiology/covid-19-risk-tool on 23 June 2020.
    1. Antonarakis SE, Skotko BG, Rafii MS, et al. Down syndrome. Nat Rev Dis Primers. 2020;6:9. [PMID: 32029743] doi:10.1038/s41572-019-0143-7 - PMC - PubMed
    1. Colvin KL, Yeager ME. What people with Down syndrome can teach us about cardiopulmonary disease. Eur Respir Rev. 2017;26. [PMID: 28223397] doi:10.1183/16000617.0098-2016 - PMC - PubMed
    1. Ram G, Chinen J. Infections and immunodeficiency in Down syndrome. Clin Exp Immunol. 2011;164:9-16. [PMID: 21352207] doi:10.1111/j.1365-2249.2011.04335.x - PMC - PubMed

Publication types