Nanostructured SmFeO3 Gas Sensors: Investigation of the Gas Sensing Performance Reproducibility for Colorectal Cancer Screening

Sensors (Basel). 2020 Oct 19;20(20):5910. doi: 10.3390/s20205910.


Among the various chemoresistive gas sensing properties studied so far, the sensing response reproducibility, i.e., the capability to reproduce a device with the same sensing performance, has been poorly investigated. However, the reproducibility of the gas sensing performance is of fundamental importance for the employment of these devices in on-field applications, and to demonstrate the reliability of the process development. This sensor property became crucial for the preparation of medical diagnostic tools, in which the use of specific chemoresistive gas sensors along with a dedicated algorithm can be used for screening diseases. In this work, the reproducibility of SmFeO3 perovskite-based gas sensors has been investigated. A set of four SmFeO3 devices, obtained from the same screen-printing deposition, have been tested in laboratory with both controlled concentrations of CO and biological fecal samples. The fecal samples tested were employed in the clinical validation protocol of a prototype for non-invasive colorectal cancer prescreening. Sensors showed a high reproducibility degree, with an error lower than 2% of the response value for the test with CO and lower than 6% for fecal samples. Finally, the reproducibility of the SmFeO3 sensor response and recovery times for fecal samples was also evaluated.

Keywords: CRC screening; chemoresistive gas sensors; gas sensor reproducibility; medical diagnostic tool; nanostructured SmFeO3 perovskite.

MeSH terms

  • Biosensing Techniques
  • Colorectal Neoplasms* / diagnosis
  • Early Detection of Cancer*
  • Humans
  • Mass Screening
  • Nanostructures*
  • Reproducibility of Results