Legius syndrome is characterized by numerous café-au-lait macules and intertriginous freckling, but typically lacks the distinctive tumor manifestations of neurofibromatosis type 1. We report two siblings with Legius syndrome and Lisch nodules illustrating the importance of eye surveillance in these patients.
Keywords: NF1; SPRED1; café‐au‐lait macules; legius syndrome; lisch nodules; neurofibromatosis type 1; neurofibromatosis type 1‐like syndrome.
Published 2020. This article is a U.S. Government work and is in the public domain in the USA. Clinical Case Reports published by John Wiley & Sons Ltd.