The mechanism of 2-deoxy-glucose-induced insulin secretion in the mouse

J Auton Pharmacol. 1987 Jun;7(2):135-44. doi: 10.1111/j.1474-8673.1987.tb00143.x.


1 Intravenous injection of 2-deoxy-glucose (3 mmol/kg) increases plasma levels of insulin and glucose in the mouse. This study investigated the contribution of various autonomic receptors to the plasma insulin response. 2 Pretreatment with the cholinergic antagonist methylatropine abolished the response completely. 3 Pretreatment with the alpha-adrenoceptor antagonist phentolamine caused a potentiated response, whereas the beta-adrenoceptor antagonist L-propranolol had no effect. 4 Pretreatment with methylatropine and phentolamine combined caused a small insulin response, which was inhibited by propranolol. 5 Pretreatment with the nicotonic antagonist hexamethonium abolished the response. 6 It is concluded that 2-deoxy-glucose induces a stimulation of insulin secretion in vivo in the mouse predominantly by a cholinergic mechanism. 7 2-Deoxy-glucose also activates alpha-adrenergic mechanisms which affect the size of the insulin secretory response. beta-Adrenoceptor and non-adrenergic, non-cholinergic mechanisms seem to be less important.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atropine Derivatives / pharmacology
  • Blood Glucose / metabolism
  • Deoxy Sugars / pharmacology*
  • Deoxyglucose / pharmacology*
  • Female
  • Hexamethonium Compounds / pharmacology
  • Insulin / blood
  • Insulin / metabolism*
  • Insulin Secretion
  • Mice
  • Phentolamine / pharmacology
  • Propranolol / pharmacology*
  • Receptors, Adrenergic / drug effects


  • Atropine Derivatives
  • Blood Glucose
  • Deoxy Sugars
  • Hexamethonium Compounds
  • Insulin
  • Receptors, Adrenergic
  • methylatropine
  • Deoxyglucose
  • Propranolol
  • Phentolamine