Update on the Use of Filters for Parenteral Nutrition: An ASPEN Position Paper

Nutr Clin Pract. 2021 Feb;36(1):29-39. doi: 10.1002/ncp.10587. Epub 2020 Oct 22.


Intravenous in-line filters play a critical role in promoting patient safety during parenteral nutrition (PN) administration. Guidelines for using filters for PN have been issued by a number of professional organizations and manufacturers of PN components. Yet despite this guidance, filter use remains controversial. Recent changes in recommendations for filtering lipid injectable emulsions have added to confusion and created considerable variation in practice. This Position Paper aims to review past guidance regarding the filtration of PN, examine the clinical consequences of infusing particulate matter, discuss the challenges and issues related to filtration, and clarify the American Society for Parenteral and Enteral Nutrition (ASPEN) recommendations for the use of filters for PN administration. This paper was approved by the ASPEN Board of Directors.

Keywords: filters; intravenous fat emulsions; lipid injectable emulsion; parenteral nutrition; patient safety.

MeSH terms

  • Enteral Nutrition
  • Fat Emulsions, Intravenous
  • Humans
  • Parenteral Nutrition*
  • Patient Safety


  • Fat Emulsions, Intravenous