Clinical manifestations and perinatal outcomes of pregnant women with COVID-19: a systematic review and meta-analysis

Sci Rep. 2020 Oct 22;10(1):18126. doi: 10.1038/s41598-020-75096-4.


This systematic review and meta-analysis aimed to evaluate the impact of COVID-19 on pregnant women. We searched for qualified studies in PubMed, Embase, and Web of Science. The clinical characteristics of pregnant women with COVID-19 and their infants were reported as means and proportions with 95% confidence interval. Eleven studies involving with 9032 pregnant women with COVID-19 and 338 infants were included in the meta-analysis. Pregnant women with COVID-19 have relatively mild symptoms. However, abnormal proportions of laboratory parameters were similar or even increased, compared to general population. Around 30% of pregnant women with COVID-19 experienced preterm delivery, whereas the mean birth weight was 2855.9 g. Fetal death and detection of SARS-CoV-2 were observed in about 2%, whereas neonatal death was found to be 0.4%. In conclusion, the current review will serve as an ideal basis for future considerations in the treatment and management of COVID-19 in pregnant women.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Betacoronavirus / isolation & purification
  • Birth Weight
  • COVID-19
  • Coronavirus Infections / complications
  • Coronavirus Infections / pathology*
  • Coronavirus Infections / virology
  • Female
  • Fetal Death / etiology
  • Humans
  • Infant, Newborn
  • Pandemics
  • Perinatal Death / etiology*
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / pathology*
  • Pneumonia, Viral / virology
  • Pregnancy
  • Premature Birth / etiology*
  • SARS-CoV-2