2020 European guideline on the management of syphilis

J Eur Acad Dermatol Venereol. 2021 Mar;35(3):574-588. doi: 10.1111/jdv.16946. Epub 2020 Oct 22.


The 2020 edition of the European guideline on the management of syphilis is an update of the 2014 edition. Main modifications and updates include: -The ongoing epidemics of early syphilis in Europe, particularly in men who have sex with men (MSM) -The development of dual treponemal and non-treponemal point-of-care (POC) tests -The progress in non-treponemal test (NTT) automatization -The regular episodic shortage of benzathine penicillin G (BPG) in some European countries -The exclusion of azithromycin as an alternative treatment at any stage of syphilis -The pre-exposure or immediate post-exposure prophylaxis with doxycycline in populations at high risk of acquiring syphilis.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Europe
  • Homosexuality, Male
  • Humans
  • Male
  • Penicillin G Benzathine
  • Sexual and Gender Minorities*
  • Syphilis Serodiagnosis
  • Syphilis* / diagnosis
  • Syphilis* / drug therapy
  • Syphilis* / epidemiology


  • Anti-Bacterial Agents
  • Penicillin G Benzathine