Database resources of the National Center for Biotechnology Information

Nucleic Acids Res. 2021 Jan 8;49(D1):D10-D17. doi: 10.1093/nar/gkaa892.


The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed® database of citations and abstracts published in life science journals. The Entrez system provides search and retrieval operations for most of these data from 34 distinct databases. The E-utilities serve as the programming interface for the Entrez system. Custom implementations of the BLAST program provide sequence-based searching of many specialized datasets. New resources released in the past year include a new PubMed interface and NCBI datasets. Additional resources that were updated in the past year include PMC, Bookshelf, Genome Data Viewer, SRA, ClinVar, dbSNP, dbVar, Pathogen Detection, BLAST, Primer-BLAST, IgBLAST, iCn3D and PubChem. All of these resources can be accessed through the NCBI home page at

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Computational Biology / methods
  • Databases, Chemical
  • Databases, Genetic*
  • Databases, Nucleic Acid
  • Databases, Protein
  • Genomics / methods
  • Humans
  • National Library of Medicine (U.S.)*
  • PubMed
  • United States