HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

Nature. 1987 Oct 15-21;329(6140):599-604. doi: 10.1038/329599a0.

Abstract

Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Base Sequence
  • Chromosomes, Human, Pair 6
  • Diabetes Mellitus, Type 1 / genetics*
  • Disease Susceptibility
  • Genetic Linkage
  • HLA-D Antigens / genetics*
  • HLA-DQ Antigens / genetics*
  • HLA-DR Antigens / genetics
  • Haploidy
  • Histocompatibility Antigens Class II / genetics
  • Humans
  • Immunity, Innate
  • Islets of Langerhans / immunology
  • Molecular Sequence Data
  • Oligonucleotides / analysis
  • Polymorphism, Genetic

Substances

  • HLA-D Antigens
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
  • Oligonucleotides