Current situation of carboplatin desensitisation protocols in the hospitals of Spain

Eur J Hosp Pharm. 2020 Nov;27(6):369-370. doi: 10.1136/ejhpharm-2018-001746. Epub 2019 Feb 20.


Desensitisation protocols allow the continuation of treatment in patients who have presented hypersensitivity reactions. Carboplatin desensitisation solutions are usually prepared in the chemotherapy centralised units of hospital pharmacies and they are diluted under the established concentration limit to guarantee the stability of the preparation. An online survey was sent to hospital pharmacies, inquiring about local desensitisation protocols: reasons for use of desensitisation protocols, the protocols used and the stability given to carboplatin solutions. An important variability among the hospitals in carboplatin desensitisation practice was detected. Six different carboplatin desensitisation protocols were described and discordance with the storage period of the carboplatin solutions was observed. The lack of consensus on which protocol must be followed and data supporting the stability of the diluted product, contribute to distrust of carboplatin desensitisation protocols. Although the efficacy and safety of carboplatin desensitisation protocols has been widely demonstrated, many professionals still have concerns.

Keywords: carboplatin; desensitisation; drug stability; hypersensibility; survey.

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Carboplatin / administration & dosage
  • Carboplatin / adverse effects*
  • Cross-Sectional Studies
  • Desensitization, Immunologic / methods*
  • Drug Hypersensitivity / diagnosis
  • Drug Hypersensitivity / drug therapy*
  • Drug Hypersensitivity / epidemiology*
  • Humans
  • Infusions, Intravenous
  • Pharmaceutical Solutions / administration & dosage
  • Pharmacy Service, Hospital / methods*
  • Pharmacy Service, Hospital / trends
  • Prospective Studies
  • Spain / epidemiology


  • Antineoplastic Agents
  • Pharmaceutical Solutions
  • Carboplatin