Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19

Yin Zhao; You Shang; Yujie Ren; Yuanyuan Bie; Yang Qiu; Yin Yuan; Yun Zhao; Li Zou; Shu-Hai Lin; Xi Zhou

doi:10.1038/s41392-020-00362-w

Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19

Signal Transduct Target Ther. 2020 Oct 23;5(1):247. doi: 10.1038/s41392-020-00362-w.

Authors

Yin Zhao¹, You Shang^{2

3}, Yujie Ren^{4

5}, Yuanyuan Bie^{3

4}, Yang Qiu^{3

4

5}, Yin Yuan⁶, Yun Zhao⁷, Li Zou⁸, Shu-Hai Lin⁹, Xi Zhou^{10

11

12}

Affiliations

¹ Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.
² Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & WuhanJinyintan Hospital, CAS, 430023, Wuhan, China.
⁴ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), 430071, Wuhan, China.
⁵ Center for Precision Translational Medicine of Wuhan Institute of Virology & Guangzhou Women and Children's Medical Center, 510120, Guangzhou, China.
⁶ State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.
⁷ Department of Obstetrics and Gynecology, Maternal and Child Hospital of Hubei Province, 430072, Wuhan, China.
⁸ Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China. xiehezouli@hust.edu.cn.
⁹ State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China. shuhai@xmu.edu.cn.
¹⁰ Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & WuhanJinyintan Hospital, CAS, 430023, Wuhan, China. zhouxi@wh.iov.cn.
¹¹ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), 430071, Wuhan, China. zhouxi@wh.iov.cn.
¹² Center for Precision Translational Medicine of Wuhan Institute of Virology & Guangzhou Women and Children's Medical Center, 510120, Guangzhou, China. zhouxi@wh.iov.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Animals
Betacoronavirus / pathogenicity*
Breast Feeding
COVID-19
Case-Control Studies
Cesarean Section
Colostrum / chemistry*
Colostrum / immunology
Colostrum / virology
Coronavirus Infections / genetics
Coronavirus Infections / immunology*
Coronavirus Infections / virology
Female
Gene Expression
Gene Expression Profiling
Humans
Infant, Newborn
Lipidomics
Metabolome / immunology
Milk Proteins / classification
Milk Proteins / genetics
Milk Proteins / immunology
Milk, Human / chemistry*
Milk, Human / immunology
Milk, Human / virology
Pandemics
Pneumonia, Viral / genetics
Pneumonia, Viral / immunology*
Pneumonia, Viral / virology
Postpartum Period
Pregnancy
Proteome / classification
Proteome / genetics*
Proteome / immunology
SARS-CoV-2

Substances

Milk Proteins
Proteome

Publication types

MeSH terms

Substances

Grants and funding