Association of antimicrobial photodynamic therapy and photobiomodulation for herpes simplex labialis resolution: Case series

Photodiagnosis Photodyn Ther. 2020 Dec:32:102070. doi: 10.1016/j.pdpdt.2020.102070. Epub 2020 Oct 21.


Antimicrobial Photodynamic Therapy (aPDT) with photobiomodulation therapy (PBT) can be used in herpes simplex and may have a role in improving modulation of inflammatory process, pain relief and acceleration of tissue repair. This article reports through a case series, a proposal for an efficient resolution in clinical manifestations of herpes simplex labialis using aPDT associated with PBT.

Keywords: Diode laser; Herpes simplex; Methylene Blue; Photodynamic therapy.

MeSH terms

  • Anti-Infective Agents* / therapeutic use
  • Herpes Labialis* / drug therapy
  • Herpes Simplex* / drug therapy
  • Humans
  • Methylene Blue / therapeutic use
  • Photochemotherapy* / methods
  • Photosensitizing Agents / therapeutic use


  • Anti-Infective Agents
  • Photosensitizing Agents
  • Methylene Blue