Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients

Nobunao Ikewaki; Masaru Iwasaki; Samuel J K Abraham

doi:10.1007/s40200-020-00664-4

Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients

J Diabetes Metab Disord. 2020 Oct 21;19(2):2041-2044. doi: 10.1007/s40200-020-00664-4. eCollection 2020 Dec.

Authors

Nobunao Ikewaki^{1

2}, Masaru Iwasaki³, Samuel J K Abraham^{3

4

5

6}

Affiliations

¹ Department of Medical Life Science, Kyushu University of Health and Welfare, Nobeoka, Japan.
² Institute of Immunology, Junsei Educational Institute, Nobeoka, Miyazaki Japan.
³ Yamanashi University- School of Medicine, Yamanashi Chuo, Japan.
⁴ Edogawa Evolutionary Laboratory of Science (EELS), Edogawa Hospital, Tokyo, Japan.
⁵ The Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India.
⁶ GN Corporation Co. Ltd, 3-8, Wakamatsu, 400-0866 Kofu, Japan.

Abstract

With the COVID-19 pandemic causing huge threat to public health and definite treatment modalities and preventive vaccines yet to be arrived at, some of the key indicators of relevance to its prognosis have started emerging. One such independent predictor of outcome has been fasting plasma glucose (FPG) at the time of admission. Earlier, co-morbidities such as diabetes also have been reported to have a risk of relatively increased mortality due to COVID-19. In this background, we herein report on the beneficial effects of Biological response modifier glucan (BRMG) secreted by the black yeast Aureobasidium pullulans AFO-202 which has been proven to bring under control blood sugar levels in human subjects and also has potential in enhancing & regulating the immune parameters in relevance to COVID-19. We further recommend that this BRMG be tried in clinical studies of COVID-19 to provide a prophylactic effect for validation.

Keywords: Biological response modifier glucan (BRMG); COVID-19; Diabetes; Fasting plasma glucose (FPG); Prophylaxis.

Publication types

Editorial