RNAcentral 2021: secondary structure integration, improved sequence search and new member databases

Nucleic Acids Res. 2021 Jan 8;49(D1):D212-D220. doi: 10.1093/nar/gkaa921.


RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million sequences, making RNAcentral the world's largest RNA 2D structure database. The 2D diagrams are displayed using R2DT, a new 2D structure visualization method that uses consistent, reproducible and recognizable layouts for related RNAs. The sequence similarity search has been updated with a faster interface featuring facets for filtering search results by RNA type, organism, source database or any keyword. This sequence search tool is available as a reusable web component, and has been integrated into several RNAcentral member databases, including Rfam, miRBase and snoDB. To allow for a more fine-grained assignment of RNA types and subtypes, all RNAcentral sequences have been annotated with Sequence Ontology terms. The RNAcentral database continues to grow and provide a central data resource for the RNA community. RNAcentral is freely available at https://rnacentral.org.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apicomplexa / classification
  • Apicomplexa / genetics
  • Base Sequence
  • Betacoronavirus / classification
  • Betacoronavirus / genetics
  • Databases, Nucleic Acid / organization & administration*
  • Databases, Nucleic Acid / supply & distribution
  • Fungi / classification
  • Fungi / genetics
  • Gene Ontology
  • Humans
  • Internet
  • Molecular Sequence Annotation*
  • Nucleic Acid Conformation
  • RNA, Untranslated / classification
  • RNA, Untranslated / genetics*
  • RNA, Untranslated / metabolism
  • Sequence Analysis, RNA
  • Software*


  • RNA, Untranslated