Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari

Org Biomol Chem. 2021 Jan 6;19(1):182-187. doi: 10.1039/d0ob02031a.

Abstract

Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fusarium / genetics
  • Fusarium / metabolism*
  • Multigene Family / genetics
  • Oxidation-Reduction
  • Tryptophan / metabolism*

Substances

  • Tryptophan

Supplementary concepts

  • Fusarium sacchari