Syndromes of acute nonlymphocytic leukemia

Ann Intern Med. 1987 Nov;107(5):748-58. doi: 10.7326/0003-4819-107-5-748.


The marriage of cytogenetics and molecular biology has resulted in major advances in our understanding of acute nonlymphocytic leukemia. These technologies reveal a number of clearly recognizable syndromes of acute nonlymphocytic leukemia. This review describes the salient features of several of these syndromes: acute myelomonocytic leukemia with abnormal eosinophils; acute nonlymphocytic leukemia with 11q abnormalities [biphenotypic leukemia with t(4;11); and acute monocytic leukemia with t(9;11)]; acute nonlymphocytic leukemia with t(8;21); acute promyelocytic leukemia; acute nonlymphocytic leukemia with normal or elevated platelet counts and rearranged 3q21 and 3q26; and acute nonlymphocytic leukemia with increased basophils and t(6;9). The pathogenesis of therapy-related leukemias is discussed also.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acute Disease
  • Basophils
  • Chromosome Aberrations
  • Chromosome Disorders
  • Eosinophils
  • Humans
  • Leukemia / blood
  • Leukemia / chemically induced
  • Leukemia / classification*
  • Leukemia / etiology
  • Leukemia / genetics
  • Leukemia, Myeloid, Acute / blood
  • Platelet Count
  • Radiotherapy / adverse effects