Role of platelet-rich plasma in the treatment of osteoarthritis: a meta-analysis

J Int Med Res. 2020 Oct;48(10):300060520964661. doi: 10.1177/0300060520964661.


Objective: The clinical efficacy of platelet-rich plasma (PRP) in the treatment of osteoarthritis remains controversial. In this paper, we evaluated the clinical efficacy of PRP in the treatment of osteoarthritis using meta-analysis, providing evidence for the selection of clinical treatment options.

Methods: We performed a computer-based search of PubMed, Embase, and the Cochrane Library databases to retrieve articles using the search terms "platelet-rich plasma", "osteoarthrosis", and "knee joint". Quality evaluation and data extraction were performed. The combined effect was assessed using RevMan 5.3 software.

Results: Five randomized controlled trials, involving 320 patients, were included in this study. No significant differences were observed in the International Knee Documentation Committee score, visual analog scale (VAS) score, or the absolute value of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score between the experimental and control groups. The absolute value of the VAS score and change in the WOMAC score were significantly decreased and patient satisfaction was increased in the experimental group, as compared with the control group.

Conclusion: The findings of this meta-analysis suggest that intra-articular injection of PRP is an effective treatment for osteoarthritis that can reduce post-operative pain, improve locomotor function, and increase patient satisfaction.

Keywords: International Knee Documentation Committee (IKDC) score; Osteoarthritis; Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score; patient satisfaction; platelet-rich plasma; randomized controlled trial.

Publication types

  • Meta-Analysis

MeSH terms

  • Humans
  • Hyaluronic Acid
  • Injections, Intra-Articular
  • Knee Joint
  • Osteoarthritis, Knee* / therapy
  • Platelet-Rich Plasma*
  • Randomized Controlled Trials as Topic
  • Treatment Outcome


  • Hyaluronic Acid