Drug Incorporation in the Drug Delivery System of Micelles

Evangelia Soumelidou; Simona Golič Grdadolnik; Thomas Mavromoustakos

doi:10.1007/978-1-0716-0920-0_8

Drug Incorporation in the Drug Delivery System of Micelles

Methods Mol Biol. 2021:2207:99-108. doi: 10.1007/978-1-0716-0920-0_8.

Authors

Evangelia Soumelidou¹, Simona Golič Grdadolnik², Thomas Mavromoustakos³

Affiliations

¹ National Kapodistrian University of Athens, Panepistimiopolis, Zografou, Greece.
² Laboratory for Molecular Structural Dynamics, National Institute of Chemistry, Ljubljana, Slovenia.
³ National Kapodistrian University of Athens, Panepistimiopolis, Zografou, Greece. tmavrom@chem.uoa.gr.

PMID: 33113130
DOI: 10.1007/978-1-0716-0920-0_8

Abstract

Micelles is a system frequently used for drug delivery. Drugs are incorporated and protected in micelles before being delivered. Nuclear magnetic resonance is a suitable technique to detect the localization and incorporation of drugs into the micelle system. Free radicals are used to further facilitate the probing of the interactions between drug and micelles. This information is critical because drug-micelle interactions determine how easily the drug will be released from micelles and therefore how easily will be delivered to the target.

Keywords: 5-DSA spin label; Captopril; Micelles; NMR; Sodium dodecyl sulfate (SDS).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Captopril* / chemistry
Captopril* / pharmacokinetics
Delayed-Action Preparations / chemistry
Delayed-Action Preparations / pharmacokinetics
Drug Carriers* / chemistry
Drug Carriers* / pharmacokinetics
Micelles*
Nuclear Magnetic Resonance, Biomolecular
Sodium Dodecyl Sulfate / chemistry*

Substances

Delayed-Action Preparations
Drug Carriers
Micelles
Sodium Dodecyl Sulfate
Captopril