Cell aging in vitro: a historical perspective

Exp Gerontol. 1987;22(4):231-48. doi: 10.1016/0531-5565(87)90002-7.

Abstract

This article describes the historical background to the demonstration by Hayflick and Moorhead that human diploid cell strains in culture have limited life-spans. I suggest that the recognition of cell aging in vitro is an example from the biological sciences of a Kuhnian scientific revolution.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival*
  • Cells, Cultured
  • Chick Embryo
  • Diploidy
  • Fibroblasts
  • HeLa Cells
  • History, 20th Century
  • Humans
  • Viral Vaccines

Substances

  • Viral Vaccines