Association between interleukin-10 gene polymorphisms and risk of oral carcinoma: A meta-analysis

Histol Histopathol. 2020 Nov;35(11):1329-1336. doi: 10.14670/HH-18-275. Epub 2020 Oct 29.

Abstract

Background: The single nucleotide polymorphisms (SNPs) of Interleukin-10 (IL-10) gene have been linked with the risk of oral carcinoma (OC) in a relatively small sample size. Our study aims to investigate the pooled associations by conducting a meta-analysis of published studies.

Methods: PubMed, Web of Science and Google Scholar databases were searched to identify eligible studies published in English before October 2019. The odds ratio (OR) with a 95% confidence interval (CI) was used to assess association. The publication bias was detected by Begg's test. Sensitivity and cumulative analyses were performed to evaluate the stability of crude results.

Results: The meta-analysis involved eight studies. Significant associations were certified between IL-10 gene -1082A/G polymorphism and susceptibility of OC for A vs. G (OR=1.817, 95% CI: 1.481-2.230), AA vs. GG (OR=3.436, 95% CI: 2.281-5.175), dominant genetic model (OR=2.913, 95% CI: 1.939-4.376), and recessive genetic model (OR=1.886, 95% CI: 1.372-2.594) in overall population, East Asians and South Asians. In addition, the significant association between -592A/C polymorphism of the gene and susceptibility of OC were detected in South Asians.

Conclusions: The meta-analysis results support that the IL-10 gene -1082G allele is a risk factor for OC in East Asians and South Asians, and IL-10 gene -592C allele is a protective factor for the disease.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-10 / genetics*
  • Mouth Neoplasms / genetics*
  • Mouth Neoplasms / immunology
  • Mouth Neoplasms / pathology
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Risk Assessment
  • Risk Factors

Substances

  • IL10 protein, human
  • Interleukin-10