Bergamot oil as an integral component of nanostructured lipid carriers and a photosensitizer for photodynamic treatment of vitiligo: Characterization and clinical experimentation

Expert Opin Drug Deliv. 2021 Jan;18(1):139-150. doi: 10.1080/17425247.2021.1844180. Epub 2020 Nov 11.

Abstract

Background: Bergamot oil (BO) is a photosensitizer that can be used for photodynamic therapy (PDT) of dermatological diseases such as vitiligo. Being an oil, it can be integrated within the lipidic matrix of nanostructured lipid carriers (NLCs) as the liquid lipid constituent, hence exhibiting a dual role. Research design and methods: NLCs were prepared with different emulsifiers and coemulsifiers, and the effect of the preparation method and formulation variables on the NLCs' size was elucidated. The prepared NLCs were further characterized for their in vitro release, viscosity, thermal behavior, and in vitro photostability. Furthermore, a preclinical photodynamic study on animal skin was conducted, followed by clinical experimentation on patients with vitiligo. Results: Results showed that BO was successfully incorporated within the NLCs. The selected NLCs formulation was in the nanometer range with a gel consistency, and it provided sustained release of BO for 24 h. NLCs improved the photostability and photodynamic properties of BO, and displayed promising preclinical and clinical results for the topical PDT of vitiligo. Expert Opinion: BO containing NLCs was proven to be promising means for PDT of vitiligo, and can be further explored in other dermatological diseases.

Keywords: Photodynamic therapy; bergamot oil; nlcs; vitiligo.

MeSH terms

  • Animals
  • Drug Carriers
  • Humans
  • Lipids
  • Nanostructures*
  • Particle Size
  • Photosensitizing Agents
  • Plant Oils
  • Vitiligo* / drug therapy

Substances

  • Drug Carriers
  • Lipids
  • Photosensitizing Agents
  • Plant Oils
  • bergamot oil