A promising novel therapy for Achilles peritendinitis: double-blind comparison of glycosaminoglycan polysulfate and high-dose indomethacin

Int J Sports Med. 1987 Aug;8(4):298-303. doi: 10.1055/s-2008-1025673.


In this double-blind trial in 60 recreational athletes suffering from Achilles peritendinitis, we compared the effect of local injections of glycosaminoglycan polysulfate (GAGPS) with oral indomethacin (IM) administered over a 2-week period. Orthotic devices were prescribed in 66% of the cases to control biomechanical errors. The results after 1-year follow-up showed that GAGPS had a good overall therapeutic effect on two-thirds of the patients compared to one-third of the IM treated. In the patients with symptoms lasting longer than 3 months, IM had an effect in only 12% while GAGPS was beneficial in 59%. Twenty-five cases of non-responders and relapses underwent a crossover treatment. Those who received IM in this second period did not benefit from this treatment while those who received GAGPS showed a moderate to good effect in 8/17 (47%) after a 2-week follow-up. A different mode of action is suggested as an explanation of the encouraging results.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Achilles Tendon*
  • Administration, Oral
  • Adult
  • Clinical Trials as Topic
  • Double-Blind Method
  • Glycosaminoglycans / therapeutic use*
  • Humans
  • Indomethacin / administration & dosage*
  • Indomethacin / therapeutic use
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Random Allocation
  • Tendinopathy / drug therapy*


  • Glycosaminoglycans
  • A73025
  • Indomethacin