Receptor kinase module targets PIN-dependent auxin transport during canalization

Science. 2020 Oct 30;370(6516):550-557. doi: 10.1126/science.aba3178.


Spontaneously arising channels that transport the phytohormone auxin provide positional cues for self-organizing aspects of plant development such as flexible vasculature regeneration or its patterning during leaf venation. The auxin canalization hypothesis proposes a feedback between auxin signaling and transport as the underlying mechanism, but molecular players await discovery. We identified part of the machinery that routes auxin transport. The auxin-regulated receptor CAMEL (Canalization-related Auxin-regulated Malectin-type RLK) together with CANAR (Canalization-related Receptor-like kinase) interact with and phosphorylate PIN auxin transporters. camel and canar mutants are impaired in PIN1 subcellular trafficking and auxin-mediated PIN polarization, which macroscopically manifests as defects in leaf venation and vasculature regeneration after wounding. The CAMEL-CANAR receptor complex is part of the auxin feedback that coordinates polarization of individual cells during auxin canalization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / enzymology*
  • Arabidopsis / genetics
  • Arabidopsis Proteins / metabolism
  • Biological Transport
  • Indoleacetic Acids / metabolism*
  • Membrane Transport Proteins / metabolism
  • Protein Interaction Mapping
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • Transcription Factors / metabolism


  • Arabidopsis Proteins
  • Indoleacetic Acids
  • Membrane Transport Proteins
  • PIN1 protein, Arabidopsis
  • Transcription Factors
  • WRKY23 protein, Arabidopsis
  • Protein Kinases