t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?

J Pediatr Hematol Oncol. 2021 Nov 1;43(8):e1164-e1167. doi: 10.1097/MPH.0000000000001986.


Background: There is no established effective treatment for patients with t(1;22)(p13;q13) acute megakaryoblastic leukemia (AMKL) and hepatic fibrosis.

Observation: Here we report the outcomes of 2 t(1;22)(p13;q13) AMKL patients with hepatic fibrosis. One patient died from liver failure despite the control of leukemia. The other patient was successfully treated with reduced-intensity chemotherapy and antifibrosis therapy with tretinoin and α-tocopheryl acetate, the hepatic fibrosis resolved and leukemia was in remission for 3 years.

Conclusions: Reduced-intensity chemotherapy plus antifibrosis therapy with tretinoin and α-tocopheryl acetate could be a treatment option for these patients with t(1;22)(p13;q13) AMKL and hepatic fibrosis.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Antioxidants / therapeutic use
  • Child, Preschool
  • Chromosomes, Human, Pair 1 / genetics*
  • Chromosomes, Human, Pair 22 / genetics*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Infant, Newborn
  • Keratolytic Agents / therapeutic use
  • Leukemia, Megakaryoblastic, Acute / complications
  • Leukemia, Megakaryoblastic, Acute / drug therapy*
  • Leukemia, Megakaryoblastic, Acute / genetics
  • Leukemia, Megakaryoblastic, Acute / pathology
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / drug therapy*
  • Liver Cirrhosis / genetics
  • Liver Cirrhosis / pathology
  • Prognosis
  • Translocation, Genetic*
  • Tretinoin / therapeutic use*
  • alpha-Tocopherol / therapeutic use*


  • Antioxidants
  • Keratolytic Agents
  • Tretinoin
  • alpha-Tocopherol