Epigenetic aspects of DC development and differentiation

Heike Chauvistré; Kristin Seré

doi:10.1016/j.molimm.2020.10.011

Epigenetic aspects of DC development and differentiation

Mol Immunol. 2020 Dec:128:116-124. doi: 10.1016/j.molimm.2020.10.011. Epub 2020 Oct 27.

Authors

Heike Chauvistré¹, Kristin Seré²

Affiliations

¹ Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
² Institute of Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany. Electronic address: kristin.sere@rwth-aachen.de.

PMID: 33126080
DOI: 10.1016/j.molimm.2020.10.011

Abstract

In this review we introduce the basic principles of epigenetic gene regulation and discuss them in the context of dendritic cell (DC) development and differentiation. Epigenetic mechanisms control the accessibility of chromatin for DNA binding proteins and thus they control gene expression. These mechanisms comprise chemical modifications of DNA and histones, chromatin remodeling and chromatin conformation. The variety of epigenetic mechanisms allow high-end fine tuning and flexibility of gene expression, a prerequisite in the process of DC lineage development.

Keywords: Chromatin accessibility; Dendritic cells; Enhancers; Epigenetic mechanisms; Gene expression regulation; Histones.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / genetics*
Cell Lineage / genetics
Chromatin / genetics
DNA Methylation / genetics
DNA-Binding Proteins / genetics
Dendritic Cells / physiology*
Epigenesis, Genetic / genetics*
Epigenomics / methods
Gene Expression / genetics*
Gene Expression Regulation / genetics
Histones / genetics
Humans

Substances

Chromatin
DNA-Binding Proteins
Histones