Epigenetic aspects of DC development and differentiation

Mol Immunol. 2020 Dec;128:116-124. doi: 10.1016/j.molimm.2020.10.011. Epub 2020 Oct 27.

Abstract

In this review we introduce the basic principles of epigenetic gene regulation and discuss them in the context of dendritic cell (DC) development and differentiation. Epigenetic mechanisms control the accessibility of chromatin for DNA binding proteins and thus they control gene expression. These mechanisms comprise chemical modifications of DNA and histones, chromatin remodeling and chromatin conformation. The variety of epigenetic mechanisms allow high-end fine tuning and flexibility of gene expression, a prerequisite in the process of DC lineage development.

Keywords: Chromatin accessibility; Dendritic cells; Enhancers; Epigenetic mechanisms; Gene expression regulation; Histones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics*
  • Cell Lineage / genetics
  • Chromatin / genetics
  • DNA Methylation / genetics
  • DNA-Binding Proteins / genetics
  • Dendritic Cells / physiology*
  • Epigenesis, Genetic / genetics*
  • Epigenomics / methods
  • Gene Expression / genetics*
  • Gene Expression Regulation / genetics
  • Histones / genetics
  • Humans

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Histones