Biologically active indolizidine alkaloids

Junmin Zhang; Susan L Morris-Natschke; Di Ma; Xiao-Fei Shang; Chen-Jie Yang; Ying-Qian Liu; Kuo-Hsiung Lee

doi:10.1002/med.21747

Biologically active indolizidine alkaloids

Med Res Rev. 2021 Mar;41(2):928-960. doi: 10.1002/med.21747. Epub 2020 Oct 31.

Authors

Junmin Zhang¹, Susan L Morris-Natschke², Di Ma¹, Xiao-Fei Shang¹, Chen-Jie Yang¹, Ying-Qian Liu¹, Kuo-Hsiung Lee²

Affiliations

¹ School of Pharmacy, Lanzhou University, Lanzhou, China.
² Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.

PMID: 33128409
DOI: 10.1002/med.21747

Abstract

Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of important biological activities. In this review, we discuss the biological activity and pharmacological effects of indolizidine alkaloids and offer new avenues toward the discovery of new and better drugs based on these naturally occurring compounds.

Keywords: biological activity; indolizidine alkaloids; natural products; pharmacological effects.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alkaloids* / pharmacology
Animals
Fungi
Indolizidines* / pharmacology
Plants

Substances

Alkaloids
Indolizidines