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. 2021 May;51(5):745-755.
doi: 10.1007/s00595-020-02166-5. Epub 2020 Nov 1.

Clinical implications of the preoperative lymphocyte C-reactive protein ratio in esophageal cancer patients

Akira Yamamoto  1 , Yuji Toiyama  2 , Yoshinaga Okugawa  1 , Takashi Ichikawa  1 , Hiroki Imaoka  1 , Hiromi Yasuda  1 , Hiroyuki Fujikawa  1 , Yoshiki Okita  1 , Takeshi Yokoe  1 , Masaki Ohi  1
Affiliations

Clinical implications of the preoperative lymphocyte C-reactive protein ratio in esophageal cancer patients

Akira Yamamoto et al. Surg Today. 2021 May.

Abstract

Purpose: We recently revealed the preoperative lymphocyte C-reactive protein ratio (LCR) to be a new marker for predicting various outcomes in malignancies. The aim of our present study was to clarify the potential utility of the preoperative LCR for predicting the perioperative risk and oncological outcome in esophageal cancer patients.

Methods: We analyzed the preoperative LCR from 153 esophageal cancer patients to clarify its clinical relevance.

Results: The preoperative LCR was significantly decreased in a stage-dependent manner, and a decreased preoperative LCR was significantly associated with the occurrence of postoperative surgical site infection. Esophageal cancer patients with a low LCR showed a poor outcome in both the overall survival and disease-free survival compared with those who had a high LCR. Multivariate analyses showed that a decreased LCR was an independent prognostic factor for both a poor overall survival and disease-free survival. A decreased preoperative LCR was an independent predictive factor for postoperative surgical site infection and significantly correlated with nutritional and inflammatory indicators. In addition, the LCR was useful for identifying esophageal cancer patients likely to have a poor outcome among patients with and without neoadjuvant chemotherapy.

Conclusions: Assessing the preoperative LCR might help physicians identify populations at high risk for perioperative complication and oncological outcomes, and determine individualized perioperative therapeutic strategies.

Keywords: Chemoradiation; Esophageal cancer; Lymphocyte C-reactive protein ratio; Prognosis; Recurrence.

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References

    1. Global Burden of Disease Cancer C, Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, et al. Global, regional, and National cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the Global burden of disease study. JAMA Oncol. 2017;3(4):524–48. - DOI
    1. Anderson LA, Tavilla A, Brenner H, Luttmann S, Navarro C, Gavin AT, et al. Survival for oesophageal, stomach and small intestine cancers in Europe 1999–2007: results from EUROCARE-5. Eur J Can. 2015;51(15):2144–57. - DOI
    1. Crusz SM, Balkwill FR. Inflammation and cancer: advances and new agents. Nature reviews. Clin Oncol. 2015;12(10):584–96.
    1. Diakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-related inflammation and treatment effectiveness. Lancet Oncol. 2014;15(11):e493–503. - DOI
    1. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–44. - DOI