Emerging Issues in Antifungal Resistance

Infect Dis Clin North Am. 2020 Dec;34(4):921-943. doi: 10.1016/j.idc.2020.05.003.

Abstract

Invasive fungal diseases continue to cause substantial mortality in the enlarging immunocompromised population. It is fortunate that the field has moved past amphotericin B deoxycholate as the only available antifungal drug but despite new classes of antifungal agents both primary and secondary drug resistance in molds and yeasts abound. From the rise of multiple-drug-resistant Candida auris to the agrochemical selection of environmental azole-resistant Aspergillus fumigatus, it is and will be critical to understand antifungal drug resistance and both prevent and treat it with new strategies and agents.

Keywords: Antifungal agents; Drug resistance; Fungi; Invasive fungal disease.

Publication types

  • Review

MeSH terms

  • Antifungal Agents / pharmacology*
  • Drug Resistance, Fungal*
  • Fungal Proteins / genetics
  • Fungi / drug effects
  • Fungi / genetics*
  • Gene Expression Regulation, Fungal / drug effects
  • Humans
  • Immunocompromised Host
  • Invasive Fungal Infections / drug therapy*
  • Invasive Fungal Infections / microbiology

Substances

  • Antifungal Agents
  • Fungal Proteins