CRC-EBD: Epigenetic Biomarker Database for Colorectal Cancer

doi:10.3389/fgene.2020.00907

. 2020 Oct 6:11:907.

doi: 10.3389/fgene.2020.00907. eCollection 2020.

CRC-EBD: Epigenetic Biomarker Database for Colorectal Cancer

Xingyun Liu^{1

2}, Xueli Zhang^{2

3

4}, Jing Chen⁵, Benchen Ye², Shumin Ren¹, Yuxin Lin², Xiao-Feng Sun⁶, Hong Zhang³, Bairong Shen^{1

2}

Affiliations

¹ Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu, China.
² Center for Systems Biology, University, Suzhou, China.
³ School of Medicine, Institute of Medical Sciences, Örebro University, Örebro, Sweden.
⁴ Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China.
⁵ School of Science, Kangda College of Nanjing Medical University, Lianyungang, China.
⁶ Department of Oncology and Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

PMID: 33133126
PMCID: PMC7573234
DOI: 10.3389/fgene.2020.00907

CRC-EBD: Epigenetic Biomarker Database for Colorectal Cancer

Xingyun Liu et al. Front Genet. 2020.

. 2020 Oct 6:11:907.

doi: 10.3389/fgene.2020.00907. eCollection 2020.

Authors

Xingyun Liu^{1

2}, Xueli Zhang^{2

3

4}, Jing Chen⁵, Benchen Ye², Shumin Ren¹, Yuxin Lin², Xiao-Feng Sun⁶, Hong Zhang³, Bairong Shen^{1

2}

Affiliations

¹ Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu, China.
² Center for Systems Biology, University, Suzhou, China.
³ School of Medicine, Institute of Medical Sciences, Örebro University, Örebro, Sweden.
⁴ Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China.
⁵ School of Science, Kangda College of Nanjing Medical University, Lianyungang, China.
⁶ Department of Oncology and Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

PMID: 33133126
PMCID: PMC7573234
DOI: 10.3389/fgene.2020.00907

No abstract available

Keywords: DNA methylation; colorectal cancer; database; epigenetics; histone modification.

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Figures

**Figure 1**
Pipeline of database construction.

**Figure 2**
Distributions of the biomarkers in CRC-EBD. **(A)** Epigenetic types. **(B)** Biomarker types. **(C)** Sample types. **(D)** Cancer types.

See this image and copyright information in PMC

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References

1. Ahmed F. E. (2007). Colorectal cancer epigenetics: the role of environmental factors and the search for molecular biomarkers. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 25, 101–154. 10.1080/10590500701399184 - DOI - PubMed
1. Bray F., Ferlay J., Soerjomataram I., Siegel R. L., Torre L. A., Jemal A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424. 10.3322/caac.21492 - DOI - PubMed
1. Danese E., Montagnana M. (2017). Epigenetics of colorectal cancer: emerging circulating diagnostic and prognostic biomarkers. Ann. Transl. Med. 5:279. 10.21037/atm.2017.04.45 - DOI - PMC - PubMed
1. Dupont C., Armant D. R., Brenner C. A. (2009). Epigenetics: definition, mechanisms and clinical perspective. Semin. Reprod. Med. 27, 351–357. 10.1055/s-0029-1237423 - DOI - PMC - PubMed
1. Ehrlich M., Gama-Sosa M. A., Huang L. H., Midgett R. M., Kuo K. C., McCune R. A., et al. . (1982). Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res. 10, 2709–2721. 10.1093/nar/10.8.2709 - DOI - PMC - PubMed

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[1] Ahmed F. E. (2007). Colorectal cancer epigenetics: the role of environmental factors and the search for molecular biomarkers. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 25, 101–154. 10.1080/10590500701399184 - DOI - PubMed

[2] Ahmed F. E. (2007). Colorectal cancer epigenetics: the role of environmental factors and the search for molecular biomarkers. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 25, 101–154. 10.1080/10590500701399184 - DOI - PubMed

[3] Bray F., Ferlay J., Soerjomataram I., Siegel R. L., Torre L. A., Jemal A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424. 10.3322/caac.21492 - DOI - PubMed

[4] Bray F., Ferlay J., Soerjomataram I., Siegel R. L., Torre L. A., Jemal A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424. 10.3322/caac.21492 - DOI - PubMed

[5] Danese E., Montagnana M. (2017). Epigenetics of colorectal cancer: emerging circulating diagnostic and prognostic biomarkers. Ann. Transl. Med. 5:279. 10.21037/atm.2017.04.45 - DOI - PMC - PubMed

[6] Danese E., Montagnana M. (2017). Epigenetics of colorectal cancer: emerging circulating diagnostic and prognostic biomarkers. Ann. Transl. Med. 5:279. 10.21037/atm.2017.04.45 - DOI - PMC - PubMed

[7] Dupont C., Armant D. R., Brenner C. A. (2009). Epigenetics: definition, mechanisms and clinical perspective. Semin. Reprod. Med. 27, 351–357. 10.1055/s-0029-1237423 - DOI - PMC - PubMed

[8] Dupont C., Armant D. R., Brenner C. A. (2009). Epigenetics: definition, mechanisms and clinical perspective. Semin. Reprod. Med. 27, 351–357. 10.1055/s-0029-1237423 - DOI - PMC - PubMed

[9] Ehrlich M., Gama-Sosa M. A., Huang L. H., Midgett R. M., Kuo K. C., McCune R. A., et al. . (1982). Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res. 10, 2709–2721. 10.1093/nar/10.8.2709 - DOI - PMC - PubMed

[10] Ehrlich M., Gama-Sosa M. A., Huang L. H., Midgett R. M., Kuo K. C., McCune R. A., et al. . (1982). Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res. 10, 2709–2721. 10.1093/nar/10.8.2709 - DOI - PMC - PubMed

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CRC-EBD: Epigenetic Biomarker Database for Colorectal Cancer

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CRC-EBD: Epigenetic Biomarker Database for Colorectal Cancer

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