'Sugarcoating' 2-deoxyglucose: mechanisms that suppress its toxic effects

Curr Genet. 2021 Feb;67(1):107-114. doi: 10.1007/s00294-020-01122-7. Epub 2020 Nov 2.


Yeast and cancer cells are metabolically similar as they use fermentation of glucose as a primary means of generating energy. Reliance on glucose fermentation makes both of these cell types highly sensitive to the toxic glucose analog, 2-deoxyglucose. Here we review the cellular and metabolic pathways that play a role in 2-deoxyglucose sensitivity and discuss how the modifications to these pathways result in acquisition of 2-deoxyglucose resistance. Insights gained from genetic and proteomic studies in yeast provide new ideas for the design of combinatorial therapies for cancer treatment.

Keywords: AMP-activated protein kinase; Hexose transporter; PP1 phosphatase; SNF1; α-Arrestin.

Publication types

  • Review

MeSH terms

  • DNA Damage / genetics*
  • Deoxyglucose / genetics*
  • Endocytosis / genetics*
  • Glucose / genetics
  • Glucose / metabolism
  • Metabolic Networks and Pathways / genetics
  • Proteomics*
  • Saccharomyces cerevisiae / genetics


  • Deoxyglucose
  • Glucose