PlacentaCellEnrich: A tool to characterize gene sets using placenta cell-specific gene enrichment analysis

Placenta. 2021 Jan 1;103:164-171. doi: 10.1016/j.placenta.2020.10.029. Epub 2020 Oct 27.

Abstract

Single-cell RNA-Sequencing (scRNA-Seq) has improved our understanding of individual cell types in the human placenta. However, placental scRNA-Seq data is not readily accessible when trying to understand how expression patterns in model systems correspond to those from first trimester human placenta. Therefore, we developed PlacentaCellEnrich, a tool that takes a gene set as input, and then reports if the input set is enriched for genes with placenta cell-specific expression patterns, based on human placenta scRNA-Seq data. The PlacentaCellEnrich tool is freely available at https://placentacellenrich.gdcb.iastate.edu/ for non-profit academic use under the MIT license.

Keywords: Cell subtype identification; Decidua; Gene enrichment; Trophoblast; scRNA-seq.

Publication types

  • Research Support, N.I.H., Extramural