PlacentaCellEnrich: A tool to characterize gene sets using placenta cell-specific gene enrichment analysis

Placenta. 2021 Jan 1:103:164-171. doi: 10.1016/j.placenta.2020.10.029. Epub 2020 Oct 27.


Single-cell RNA-Sequencing (scRNA-Seq) has improved our understanding of individual cell types in the human placenta. However, placental scRNA-Seq data is not readily accessible when trying to understand how expression patterns in model systems correspond to those from first trimester human placenta. Therefore, we developed PlacentaCellEnrich, a tool that takes a gene set as input, and then reports if the input set is enriched for genes with placenta cell-specific expression patterns, based on human placenta scRNA-Seq data. The PlacentaCellEnrich tool is freely available at for non-profit academic use under the MIT license.

Keywords: Cell subtype identification; Decidua; Gene enrichment; Trophoblast; scRNA-seq.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Female
  • Gene Expression Profiling
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Organ Specificity / genetics
  • Placenta* / cytology
  • Placenta* / metabolism
  • Pregnancy
  • RNA / analysis
  • RNA / genetics
  • RNA-Seq / methods*
  • Sequence Analysis, RNA / methods
  • Single-Cell Analysis / methods*
  • Software


  • RNA