Two-dimensional metal organic frameworks for biomedical applications

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Mar;13(2):e1674. doi: 10.1002/wnan.1674. Epub 2020 Nov 2.

Abstract

Two-dimensional (2D) metal organic frameworks (MOFs), are an emerging class of layered nanomaterials with well-defined structure and modular composition. The unique pore structure, high flexibility, tunability, and ability to introduce desired functionality within the structural framework, have led to potential use of MOFs in biomedical applications. This article critically reviews the application of 2D MOFs for therapeutic delivery, tissue engineering, bioimaging, and biosensing. Further, discussion on the challenges and strategies in next generation of 2D MOFs are also included. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

Keywords: bioimaging; biosensing; drug delivery; metal organic frameworks (MOFs); tissue engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biosensing Techniques
  • Diagnostic Imaging
  • Drug Delivery Systems
  • Metal-Organic Frameworks*
  • Nanostructures*
  • Tissue Engineering

Substances

  • Metal-Organic Frameworks