Congenital Neuroblastoma

Neoreviews. 2020 Nov;21(11):e716-e727. doi: 10.1542/neo.21-11-e716.


Neuroblastoma is the most common extracranial solid tumor diagnosed during childhood and gives rise to various heterogeneous tumors along the sympathoadrenal axis. Congenital neuroblastoma accounts for 5% of total neuroblastoma cases diagnosed annually, with the majority of cases diagnosed in the first month after birth. Interestingly, neonates demonstrate a unique disease trajectory compared with children older than 1 year of age. This article will provide information on the pathogenesis and variable clinical presentation of congenital neuroblastoma, along with the biological prognostic factors that predict long-term outcomes in affected neonates.

MeSH terms

  • Humans
  • Infant
  • Infant, Newborn
  • Neuroblastoma / congenital*
  • Neuroblastoma / diagnosis
  • Neuroblastoma / therapy
  • Prognosis