Development of rare-earth oxide reinforced magnesium nanocomposites for orthopaedic applications: A mechanical/immersion/biocompatibility perspective

Milli Suchita Kujur; Vyasaraj Manakari; Gururaj Parande; Somasundaram Prasadh; Raymond Wong; Ashis Mallick; Manoj Gupta

doi:10.1016/j.jmbbm.2020.104162

Development of rare-earth oxide reinforced magnesium nanocomposites for orthopaedic applications: A mechanical/immersion/biocompatibility perspective

J Mech Behav Biomed Mater. 2021 Feb:114:104162. doi: 10.1016/j.jmbbm.2020.104162. Epub 2020 Oct 27.

Authors

Milli Suchita Kujur¹, Vyasaraj Manakari², Gururaj Parande³, Somasundaram Prasadh⁴, Raymond Wong⁵, Ashis Mallick⁶, Manoj Gupta⁷

Affiliations

¹ Department of Mechanical Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, India; Department of Mechanical Engineering, National University of Singapore, Singapore. Electronic address: millisuchitakujur@gmail.com.
² Department of Mechanical Engineering, National University of Singapore, Singapore. Electronic address: mbvyasaraj@u.nus.edu.
³ Department of Mechanical Engineering, National University of Singapore, Singapore. Electronic address: gururaj.parande@u.nus.edu.
⁴ Faculty of Dentistry, National University of Singapore, Singapore. Electronic address: denrwcw@nus.edu.sg.
⁵ Faculty of Dentistry, National University of Singapore, Singapore. Electronic address: e0204949@u.nus.edu.
⁶ Department of Mechanical Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, India. Electronic address: mallick@iitism.ac.in.
⁷ Department of Mechanical Engineering, National University of Singapore, Singapore. Electronic address: mpegm@nus.edu.sg.

PMID: 33144044
DOI: 10.1016/j.jmbbm.2020.104162

Abstract

Magnesium-Zinc based nanocomposites containing cerium oxide nanoparticles were developed in the present work. A systematic study on their microstructure, mechanical properties, in vitro degradation behaviour, and cytotoxicity are presented. It was found that the developed nanocomposites exhibited excellent strength and toughness that are superior to the commercially available magnesium alloys. From corrosion perspective, nanocomposites exhibited reduced pH increase compared to pure Mg with Mg-0.5Zn/0.5CeO₂ showing the least corrosion rate. Moreover, the developed nanocomposites exhibited no cytotoxicity to MC3T3-E1 pre-osteoblast cells. Based on the above findings, the feasibility of Mg-Zn/CeO₂ nanocomposites for use as orthopaedic implants is systematically discussed. This study provides an insight into the development of new high-performance Mg alloy-rare earth oxide (REO)-based nanocomposites with superior mechanical properties and corrosion resistance while effectively avoiding the possible standing toxic effect of RE elements.

Keywords: Biodegradation; Biomaterial; Magnesium; Nanocomposite; Rare earth oxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absorbable Implants
Alloys
Biocompatible Materials / toxicity
Corrosion
Immersion
Magnesium
Materials Testing
Nanocomposites*
Orthopedics*
Oxides

Substances

Alloys
Biocompatible Materials
Oxides
Magnesium