A New Generation of "Magic Bullets" for Molecular Targeting of Cancer

Jacek Capala; Charles A Kunos

doi:10.1158/1078-0432.CCR-20-3690

A New Generation of "Magic Bullets" for Molecular Targeting of Cancer

Clin Cancer Res. 2021 Jan 15;27(2):377-379. doi: 10.1158/1078-0432.CCR-20-3690. Epub 2020 Nov 3.

Authors

Jacek Capala¹, Charles A Kunos²

Affiliations

¹ Division of Cancer Therapy and Diagnosis, NCI, NIH, Bethesda, Maryland. capalaj@mail.nih.gov.
² Division of Cancer Therapy and Diagnosis, NCI, NIH, Bethesda, Maryland.

PMID: 33144340
DOI: 10.1158/1078-0432.CCR-20-3690

Abstract

A two-step molecular targeting approach involving a self-assembling and disassembling (SADA) bispecific antibody platform and DOTA-radioconjugates allows tumor-specific delivery of diagnostic and therapeutic payloads. Low immunogenicity and the modular nature of SADA allow its optimization to safely and repeatedly deliver a variety of payloads to tumors expressing diverse tumor-specific antigens.See related article by Santich et al., p. 532.

Publication types

Comment

MeSH terms

Antibodies, Bispecific*
Antigens, Neoplasm
Humans
Molecular Targeted Therapy
Neoplasms* / diagnosis
Neoplasms* / genetics
Radioimmunotherapy

Substances

Antibodies, Bispecific
Antigens, Neoplasm