Does colchicine work? The results of the first controlled study in acute gout

Aust N Z J Med. 1987 Jun;17(3):301-4. doi: 10.1111/j.1445-5994.1987.tb01232.x.


We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two-thirds of colchicine-treated patients improved after 48 hours, but only one-third of the patients receiving placebo demonstrated similar improvement. The colchicine-treated patients responded earlier; significant differences from placebo were shown after 18-30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Clinical Trials as Topic
  • Colchicine / administration & dosage
  • Colchicine / adverse effects
  • Colchicine / therapeutic use*
  • Female
  • Gout / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Pain Measurement


  • Colchicine