Aims: We review the current literatures to determine whether intermittent phototherapy is more effective than continuous phototherapy in treating neonatal hyperbilirubinaemia.
Design: The systematic review is a systematic review and meta-analysis. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were used for reporting methods and results of synthesis with meta-analysis. Synthesis Without Meta-analysis (SWIM) guidelines were used for reporting methods and results of synthesis without meta-analysis.
Data source: Pubmed, Embase, Cochrane library, China National Knowledge Infrastructure, China Biology Medicine, VIP Database, and Wanfang Database.
Review methods: PICOS eligibility criteria were used to select original studies published from 1984 through 2019. Data were statistically extracted and evaluated using RevMan 5.3 software.
Results: A total of 416 records were identified through database searching. Four studies (three randomized studies and one retrospective study) meet the final inclusion criteria. Seven hundred and sixteen neonates were included in the meta-analysis. There was no difference in the treatment efficacy and total serum bilirubin (TSB), while there was a significant difference in phototherapy duration and side effects after treatment of intermittent phototherapy and continuous phototherapy for neonatal hyperbilirubinaemia.
Conclusion: Intermittent phototherapy appeared to be as effective as continuous phototherapy for the treatment of neonatal hyperbilirubinaemia and is safer than continuous phototherapy. Healthcare organizations and health workers should choose intermittent phototherapy as the preferred therapy for neonatal hyperbilirubinaemia.
Impact: Intermittent phototherapy is an effective, feasible, and safer treatment method for the infants with hyperbilirubinaemia in paediatric department. Healthcare organizations and health workers should choose intermittent phototherapy as the preferred therapy for neonatal hyperbilirubinaemia.
目标: 我们对现有的文献作出评价,以确定间歇光疗是否比连续光疗更有效地治疗新生儿高胆红素血症。 设计: 系统性回顾指的是进行系统评价和荟萃分析。系统评价和荟萃分析的首选报告项目(PRISMA)指南用于报告带荟萃分析的综合分析方法和结果。不带荟萃分析的综合分析(SWIM)指南用于报告不带荟萃分析的综合分析方法和结果。 数据来源: 国际文献数据库(PubMed)、荷兰医学文摘数据库(Embase)、Cochrane 临床对照试验中心注册数据库、中国国家知识基础设施、中国生物医学文献数据库、维普中文科技期刊数据库、万方数据库(WANFANG)。 评价方法: 使用工艺信息和控制系统(PICOS)资格标准选择1984年至2019年发表的原创研究。使用RevMan 5.3软件对数据进行统计提取和评估。 结果: 通过数据库检索,共识别出416条记录。四项研究(三项随机研究和一项回顾性研究)符合最终入选标准。共有716例新生儿纳入荟萃分析。新生儿高胆红素血症经间歇光疗和连续光疗治疗后,疗效及血清总胆红素(TSB)无明显差别,但光疗时间和副作用存在显著性差异。 结论: 对于治疗新生儿高胆红素血症,间歇光疗和连续光疗的疗效相同,且比连续光疗更安全。因此,在治疗新生儿高胆红素血症时,应选择间歇光疗作为首选的治疗方法。 影响: 在儿科中,运用间歇光疗治疗新生儿高胆红素血症是一种有效的、可行的、安全的治疗方法。因此,在治疗新生儿高胆红素血症时,应选择间歇光疗作为首选的治疗方法。.
Keywords: continuous; efficacy; frequency; intermittent; literature review; meta-analysis; neonatal hyperbilirubinaemia; nursing; phototherapy; safety.
© 2020 John Wiley & Sons Ltd.