Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer's disease

Ann Clin Transl Neurol. 2020 Dec;7(12):2475-2480. doi: 10.1002/acn3.51237. Epub 2020 Nov 5.


Antemortem tau positron emission tomography imaging suggests elevated tau pathology in autosomal dominant versus late-onset Alzheimer's disease at equivalent clinical stages, but does not implicate the specific tau pathologies responsible. Here we made stereological measurements of tau neurofibrillary tangles, neuritic plaques, and neuropil threads and found compared to late-onset Alzheimer's disease, autosomal dominant Alzheimer's disease showed even greater tangle and thread burdens. Regional tau burden resembled that observed in tau imaging of a separate cohort at earlier clinical stages. Finally, our results suggest tau imaging measures total tau burden in Alzheimer's disease, composed predominantly of tangle and thread pathology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease* / diagnostic imaging
  • Alzheimer Disease* / metabolism
  • Alzheimer Disease* / pathology
  • Autopsy
  • Carbolines
  • Female
  • Frontal Lobe* / diagnostic imaging
  • Frontal Lobe* / metabolism
  • Frontal Lobe* / pathology
  • Humans
  • Male
  • Middle Aged
  • Parietal Lobe* / diagnostic imaging
  • Parietal Lobe* / metabolism
  • Parietal Lobe* / pathology
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • tau Proteins / metabolism*


  • Carbolines
  • MAPT protein, human
  • Radiopharmaceuticals
  • tau Proteins
  • 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole