Corticotropin-releasing factor (CRF) produces analgesia in humans and rats

Brain Res. 1987 Sep 29;422(1):154-7. doi: 10.1016/0006-8993(87)90550-6.


The analgesic activity of corticotropin releasing factor (CRF) was determined in a clinical model and in the rat hot plate test. Patients administered CRF reported significantly less postoperative pain than patients pretreated with placebo. In rats, injection of CRF resulted in a significant analgesia which was comparable in both intensity and duration to a 300 times greater molar dose of morphine. These findings suggest that endogenous CRF may play a physiologic role in modulating pain when released under conditions of stress.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Analgesia*
  • Animals
  • Clinical Trials as Topic
  • Corticotropin-Releasing Hormone / administration & dosage*
  • Corticotropin-Releasing Hormone / physiology
  • Humans
  • Injections, Intravenous
  • Male
  • Pain / drug therapy*
  • Pain, Postoperative / drug therapy
  • Random Allocation
  • Rats
  • Time Factors


  • Corticotropin-Releasing Hormone