DrugCentral 2021 supports drug discovery and repositioning

Nucleic Acids Res. 2021 Jan 8;49(D1):D1160-D1169. doi: 10.1093/nar/gkaa997.

Abstract

DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018 through March 2020) active pharmaceutical ingredients in the US, Europe, Japan and other countries; and two molecular entities (e.g. mefuparib) of interest for COVID19. New additions include a set of pharmacokinetic properties for ∼1000 drugs, and a sex-based separation of side effects, processed from FAERS (FDA Adverse Event Reporting System); as well as a drug repositioning prioritization scheme based on the market availability and intellectual property rights forFDA approved drugs. In the context of the COVID19 pandemic, we also incorporated REDIAL-2020, a machine learning platform that estimates anti-SARS-CoV-2 activities, as well as the 'drugs in news' feature offers a brief enumeration of the most interesting drugs at the present moment. The full database dump and data files are available for download from the DrugCentral web portal.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / adverse effects
  • Antiviral Agents / pharmacokinetics
  • Antiviral Agents / therapeutic use*
  • COVID-19 / drug therapy*
  • COVID-19 / epidemiology
  • COVID-19 / virology
  • Databases, Pharmaceutical / statistics & numerical data*
  • Drug Approval / methods
  • Drug Approval / statistics & numerical data*
  • Drug Discovery / methods
  • Drug Discovery / statistics & numerical data*
  • Drug Repositioning / methods
  • Drug Repositioning / statistics & numerical data*
  • Epidemics
  • Europe
  • Humans
  • Information Storage and Retrieval / methods
  • Internet
  • Japan
  • SARS-CoV-2 / drug effects*
  • SARS-CoV-2 / physiology
  • United States

Substances

  • Antiviral Agents