Abstract
One class of molecules that are now coming to be recognized as essential for our understanding of the nervous system are the lysophospholipids. One of the major signaling lysophospholipids is lysophosphatidic acid, also known as LPA. LPA activates a variety of G protein-coupled receptors (GPCRs) leading to a multitude of physiological responses. In this review, I describe our current understanding of the role of LPA and LPA receptor signaling in the development and function of the nervous system, especially the central nervous system (CNS). In addition, I highlight how aberrant LPA receptor signaling may underlie neuropathological conditions, with important clinical application.
Keywords:
Autotaxin; Axon guidance; Cortical development; LPA receptors; Lysophospholipid; Neuropathic pain.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Axons / ultrastructure
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Brain / embryology
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Brain / growth & development
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Brain / metabolism
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Brain Injuries / physiopathology
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Central Nervous System / physiopathology*
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Cerebrovascular Disorders / physiopathology
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Diabetic Retinopathy / physiopathology
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Glaucoma / physiopathology
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Humans
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Lysophospholipids
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Mice
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Mice, Knockout
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Nerve Tissue Proteins / physiology
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Neural Stem Cells / metabolism
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Neuralgia / physiopathology
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Neurodevelopmental Disorders / genetics
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Neurodevelopmental Disorders / physiopathology
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Neuroglia / cytology
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Neuroglia / metabolism
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Rats
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Receptors, G-Protein-Coupled / physiology
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Receptors, Lysophosphatidic Acid / physiology
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Signal Transduction / physiology*
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Spinal Cord Injuries / physiopathology
Substances
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Lysophospholipids
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Nerve Tissue Proteins
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Receptors, G-Protein-Coupled
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Receptors, Lysophosphatidic Acid
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lysophosphatidic acid