Biphenyl-type neolignans from stem bark of Magnolia officinalis with potential anti-tumor activity

Heng-Fan Ni; Xiaoying Cai; Xiang Qiu; Lin Liu; Xu Ma; Li Wan; Haoyu Ye; Lijuan Chen

doi:10.1016/j.fitote.2020.104769

Biphenyl-type neolignans from stem bark of Magnolia officinalis with potential anti-tumor activity

Fitoterapia. 2020 Nov:147:104769. doi: 10.1016/j.fitote.2020.104769. Epub 2020 Nov 2.

Authors

Heng-Fan Ni¹, Xiaoying Cai², Xiang Qiu¹, Lin Liu¹, Xu Ma², Li Wan³, Haoyu Ye⁴, Lijuan Chen⁵

Affiliations

¹ The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People's Republic of China.
² Laboratory of Natural Product Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
³ The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People's Republic of China. Electronic address: wanli@cdutcm.edu.cn.
⁴ Laboratory of Natural Product Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address: haoyu_ye@scu.edu.cn.
⁵ The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People's Republic of China; Laboratory of Natural Product Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.

PMID: 33152462
DOI: 10.1016/j.fitote.2020.104769

Abstract

Six new biphenyl-type neolignans (1-6), and eighteen known compounds (7-24) were isolated from the EtOH extract of Magnolia officinalis. Their structures were determined by 1D and 2D NMR, and by HRMS. The anti-tumor activities of the isolated compounds were evaluated on HepG2, HCT-116, H1975 and HUVEC cell lines. Among the isolated compounds, nine compounds (3, 5, 7, 8, 12, 14, 20, 22, and 24) showed moderate cytotoxicities, and compound 23 showed the best cytotoxicity with IC₅₀ value lower than 10 μM.

Keywords: Anti-tumor activity; Cytotoxicity; Magnolia officinalis; Neolignans.

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Biphenyl Compounds
China
HCT116 Cells
Hep G2 Cells
Human Umbilical Vein Endothelial Cells
Humans
Lignans / isolation & purification
Lignans / pharmacology*
Magnolia / chemistry*
Molecular Structure
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Plant Bark / chemistry

Substances

Antineoplastic Agents, Phytogenic
Biphenyl Compounds
Lignans
Phytochemicals
diphenyl