Electrochemical behaviour of piperine. Comparison with control antioxidants

Food Chem. 2021 Mar 1;339:128110. doi: 10.1016/j.foodchem.2020.128110. Epub 2020 Sep 17.


Piperine, as the most abundant alkaloid in pepper, gained a lot of attention for possible antioxidant and therapeutic properties. Electrochemical techniques were applied to widely evaluate the redox behavior of piperine by comparison to that of well-known antioxidants: ascorbic acid, protocatechuic acid, syringic acid, tyrosine and capsaicin used as controls. Also, electrochemistry was involved in an innovative way to investigate the potential antioxidant properties of piperine combined with different in vitro peroxidation and reducing assays: (i) 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) scavenging; (ii) 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO) scavenging; (iii) ferric ions (Fe3+) reducing power; (iv) hydrogen peroxide (H2O2) scavenging. Results show that piperine readily reacts with highly oxidizing radicals and bind redox-active metal ions in a similar manner as antioxidants used as model.

Keywords: Electrooxidation; Piperine; Potential antioxidant properties; Radical scavenging.

Publication types

  • Comparative Study

MeSH terms

  • Alkaloids / chemistry*
  • Antioxidants / chemistry*
  • Ascorbic Acid / chemistry
  • Benzodioxoles / chemistry*
  • Biphenyl Compounds / chemistry
  • Cyclic N-Oxides / chemistry
  • Electrochemical Techniques
  • Free Radical Scavengers / chemistry
  • Free Radicals / metabolism
  • Hydrogen Peroxide / chemistry
  • Iron / chemistry
  • Oxidation-Reduction
  • Picrates / chemistry
  • Piperidines / chemistry*
  • Polyunsaturated Alkamides / chemistry*


  • Alkaloids
  • Antioxidants
  • Benzodioxoles
  • Biphenyl Compounds
  • Cyclic N-Oxides
  • Free Radical Scavengers
  • Free Radicals
  • Picrates
  • Piperidines
  • Polyunsaturated Alkamides
  • Hydrogen Peroxide
  • 1,1-diphenyl-2-picrylhydrazyl
  • Iron
  • Ascorbic Acid
  • piperine