Potential Influence of Helminth Molecules on COVID-19 Pathology

Trends Parasitol. 2021 Jan;37(1):11-14. doi: 10.1016/j.pt.2020.10.002. Epub 2020 Oct 15.

Abstract

In recent months, the parasitology research community has been tasked with investigation of the influence of parasite coinfection on coronavirus disease 2019 (COVID-19) outcomes. Herein, we share our approach to analyze the effect of the trematode Fasciola hepatica as a modulator of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and of COVID-19 pathology.

Keywords: COVID-19; Fasciola hepatica; helminth parasites; infection modulation; pathology modulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigenic Modulation
  • COVID-19 / mortality
  • COVID-19 / parasitology
  • COVID-19 / pathology
  • COVID-19 / therapy*
  • Coinfection*
  • Fasciola hepatica / metabolism
  • Fascioliasis*
  • Helminth Proteins / therapeutic use*
  • Humans
  • Immunity, Innate
  • Immunologic Factors / therapeutic use
  • Inflammation / prevention & control
  • Respiratory Distress Syndrome / prevention & control

Substances

  • Helminth Proteins
  • Immunologic Factors