An improved overall risk probability-based method for assessing the combined health risks of chemical mixtures: An example about mixture of aflatoxin B1 and microcystin LR by dietary intake

Yun Li; JiaSheng Wang; JinJuan Li; XiuLan Sun

doi:10.1016/j.fct.2020.111815

An improved overall risk probability-based method for assessing the combined health risks of chemical mixtures: An example about mixture of aflatoxin B₁ and microcystin LR by dietary intake

Food Chem Toxicol. 2020 Dec:146:111815. doi: 10.1016/j.fct.2020.111815. Epub 2020 Nov 4.

Authors

Yun Li¹, JiaSheng Wang², JinJuan Li³, XiuLan Sun⁴

Affiliations

¹ State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; Key Laboratory of Agro-products Safety and Quality of the Ministry of Agriculture, Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, No. 12, Zhongguancun South Street, Beijing, 100081, PR China. Electronic address: GZ-liyun@126.com.
² State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu, 214122, PR China.
³ Key Laboratory of Agro-products Safety and Quality of the Ministry of Agriculture, Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, No. 12, Zhongguancun South Street, Beijing, 100081, PR China.
⁴ State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu, 214122, PR China. Electronic address: sxlzzz@jiangnan.edu.cn.

PMID: 33157167
DOI: 10.1016/j.fct.2020.111815

Abstract

Previous studies on the risk assessment of chemicals with respect to human health have focused mainly on the safety of individual substances. Recently, public health policy emphasizes the combined effects of mixtures. An overall risk probability (ORP)-based method long with the combined toxicity factor (c_uv) can be used to evaluate the combined toxicity of chemical mixtures from the environment and foods on human health. However, the procedure for calculating the c_uv accurately and quantitatively in the ORP method is yet unclear. In this study, an improved ORP-based method (IORP) was developed by introducing a variable time t, and the c_uv was analyzed quantitatively using simultaneous equations and based on the principle of least squares regression. This phenomenon can be explained based on the example of the mixture of aflatoxin B₁ (AFB₁) and microcystin LR (MC-LR) by dietary intake in order to understand the application of this method. The IORP approach makes it possible for estimating the combined effects of mixtures for human health by dietary pathway.

Keywords: Aflatoxin B(1); An improved overall risk probability-based method; Combined toxicity factor; Microcystin LR; Probabilistic assessment.

MeSH terms

Aflatoxin B1 / administration & dosage
Aflatoxin B1 / toxicity*
Complex Mixtures / toxicity*
Dietary Exposure*
Humans
Marine Toxins / administration & dosage
Marine Toxins / toxicity*
Microcystins / administration & dosage
Microcystins / toxicity*
Probability
Risk Assessment

Substances

Complex Mixtures
Marine Toxins
Microcystins
Aflatoxin B1
cyanoginosin LR