Clinical observation of the combined use of propofol and etomidate in painless gastroscopy

Medicine (Baltimore). 2020 Nov 6;99(45):e23061. doi: 10.1097/MD.0000000000023061.


Objective: This study is aims to compare the anesthetic safety of propofol combined with etomidate for painless gastroscopy.

Methods: Three hundred patients undergoing painless gastroscopy were randomly assigned to P, PE1, and PE2 groups. Patients were anesthetized with propofol (P group) or propofol combined with etomidate (volume ratio 1: 1, PE1 group; volume ratio 2: 1, PE2 group). The hemodynamics and adverse reactions were observed. The sleep quality satisfaction and nature of dreams were recorded.

Results: Compared with pre-anesthesia, the mean arterial pressure and heart rate of the 3 groups were significantly slower during the examination and at the end of the examination. PE1 group had a higher incidence of muscle spasm, body moving, choking, and deglutition. The incidence of hypoxemia and injection pain was higher in P group. P and PE2 group had higher sleep quality satisfaction and dream incidence after awaking. However, there was no difference in the nature of dreams among 3 groups.

Conclusion: Our data indicate that the combination of 10 ml 1.0% propofol and 5 ml 0.2% etomidate for painless gastroscopy reduces adverse reactions while not affecting the patients respiratory function. Moreover, it is safe and effective, which is worthy of clinical application and promotion.

MeSH terms

  • Adult
  • Airway Obstruction / chemically induced
  • Anesthetics, Intravenous / administration & dosage
  • Anesthetics, Intravenous / adverse effects*
  • Arterial Pressure / drug effects
  • Case-Control Studies
  • Drug Therapy, Combination
  • Etomidate / administration & dosage
  • Etomidate / adverse effects*
  • Female
  • Gastroscopy / methods*
  • Gastroscopy / trends
  • Heart Rate / drug effects
  • Hemodynamics / drug effects
  • Humans
  • Hypoxia / chemically induced
  • Incidence
  • Injection Site Reaction
  • Male
  • Middle Aged
  • Myoclonus / chemically induced
  • Propofol / administration & dosage
  • Propofol / adverse effects*
  • Safety
  • Spasm / chemically induced
  • Spasm / epidemiology
  • Treatment Outcome


  • Anesthetics, Intravenous
  • Propofol
  • Etomidate