Guideline recommendations and the positioning of newer drugs in type 2 diabetes care

Lancet Diabetes Endocrinol. 2021 Jan;9(1):46-52. doi: 10.1016/S2213-8587(20)30343-0. Epub 2020 Nov 4.


Cardiovascular outcome trials in patients with type 2 diabetes at high cardiovascular risk have led to remarkable advances in our understanding of the effectiveness of GLP-1 receptor agonists and SGLT2 inhibitors to reduce cardiorenal events. In 2019, the American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD), and European Society of Cardiology (ESC) published updated recommendations for the management of such patients. We are concerned that ongoing discussions focusing on the differences between the endocrinologists' consensus report from the ADA and EASD and cardiologists' guidelines from the ESC are contributing to clinical inertia, thereby effectively denying evidence-based treatments advocated by both groups to patients with type 2 diabetes and cardiorenal disease. A subset of members from the writing groups of the ADA-EASD consensus report and the ESC guidelines was convened to emphasise where commonalities exist and to propose an integrated framework that encompasses the views incorporated in management approaches proposed by the ESC and the ADA and EASD. Coordinated action is required to ensure that people with type 2 diabetes, cardiovascular disease, heart failure, or chronic kidney disease are treated appropriately with an SGLT2 inhibitor or GLP-1 receptor agonist. In our opinion, this course should be initiated independent of background therapy, current glycaemic control, or individualised treatment goals.

Trial registration: NCT04007926.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Consensus
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Drug Repositioning / methods
  • Drug Repositioning / standards
  • Drugs, Investigational / therapeutic use*
  • Evidence-Based Practice / methods
  • Evidence-Based Practice / standards
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Individuality
  • Patient Care Planning / standards
  • Practice Guidelines as Topic / standards*
  • Societies, Medical / standards


  • Drugs, Investigational
  • Hypoglycemic Agents

Associated data