Antibiotic prophylaxis with cefuroxime in arthroplasty of the knee

J Bone Joint Surg Br. 1987 Nov;69(5):787-9. doi: 10.1302/0301-620X.69B5.3316240.


A randomised prospective trial was undertaken of antibiotic prophylaxis given at various intervals before inflation of the tourniquet for arthroplasty of the knee. Cefuroxime assays of bone and subcutaneous fat from samples collected throughout the operation demonstrated that an interval of 10 minutes was necessary to obtain adequate prophylaxis. Improvement in the timing of antibiotic prophylaxis may result in a reduction in the incidence of infection.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism
  • Bone and Bones / metabolism
  • Cefuroxime / pharmacokinetics
  • Cefuroxime / therapeutic use*
  • Cephalosporins / therapeutic use*
  • Clinical Trials as Topic
  • Humans
  • Intraoperative Period
  • Knee Prosthesis*
  • Premedication*
  • Prospective Studies
  • Random Allocation
  • Surgical Wound Infection / prevention & control
  • Time Factors
  • Tourniquets


  • Cephalosporins
  • Cefuroxime